Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 5(th) Floor, CABA, Buenos Aires, Argentina.
Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Hospital de Clínicas José de San Martin, Buenos Aires, Argentina.
Clin Res Hepatol Gastroenterol. 2020 Jun;44(3):368-374. doi: 10.1016/j.clinre.2019.07.006. Epub 2019 Aug 30.
Intrahepatic cholestasis of pregnancy (ICP) is considered a high-risk condition because it may have serious consequences for the fetus health. ICP is characterized by the accumulation of bile acids in maternal serum which contribute to an imbalance between the production of reactive oxygen species and the antioxidant defenses increasing the oxidative stress experienced by the fetus. Previously, it was reported a significant decrease in plasma coenzyme Q10 (CoQ10) in women with ICP. CoQ10 is a redox substance integrated in the mitochondrial respiratory chain and is recognized as a potent antioxidant playing an intrinsic role against oxidative damage. The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.
CoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n=23) and in those complicated with ICP (n=13), were investigated.
A significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105±0.010 vs. 0.069±0.011, P<0.05, normal pregnancy vs. ICP, respectively), together with an increase of total serum bile acids (2.10±0.02 vs. 7.60±2.30, P<0.05, normal pregnancy vs. ICP, respectively) was observed.
A fetus from an ICP mother is exposed to a greater risk derived from oxidative damage. The recognition of CoQ10 deficiency is important since it could be the starting point for a new and safe intervention strategy which can establish CoQ10 as a promising candidate to prevent the risk of oxidative stress.
妊娠肝内胆汁淤积症（ICP）被认为是一种高危情况，因为它可能对胎儿健康产生严重后果。ICP 的特征是母血清胆汁酸积聚，导致活性氧产生与抗氧化防御之间的不平衡，增加胎儿所经历的氧化应激。此前有报道称，ICP 妇女的血浆辅酶 Q10（CoQ10）显著下降。CoQ10 是一种氧化还原物质，整合在线粒体呼吸链中，被认为是一种有效的抗氧化剂，对氧化损伤具有内在作用。本研究旨在探讨正常妊娠和 ICP 孕妇脐带血中 CoQ10 的水平，并与母体进行比较。
研究了 23 例正常妊娠和 13 例 ICP 孕妇的母血和脐血 CoQ10 水平和胆汁酸水平。
新生儿 CoQ10 水平显著下降（经胆固醇校正后，0.105±0.010 与 0.069±0.011，P<0.05，正常妊娠与 ICP 分别），总血清胆汁酸增加（2.10±0.02 与 7.60±2.30，P<0.05，正常妊娠与 ICP 分别）。
ICP 母亲的胎儿面临更大的氧化损伤风险。认识到 CoQ10 缺乏很重要，因为它可能是一种新的、安全的干预策略的起点，可以将 CoQ10 确立为预防氧化应激风险的有前途的候选物。
