Cano A, Parrilla J J, Abad L
Department of Obstetrics and Gynecology, Facultad de Medicina, Espinardo, Murcia, Spain.
Gynecol Obstet Invest. 1988;26(4):308-12. doi: 10.1159/000293711.
Serum concentrations of PRL, LH and FSH were examined in 17 perimenopausal women with dysfunctional uterine bleeding (PDUB group), after stimulation with exogenous GnRH (a 100-micrograms i.v. bolus dose), and endogenous GnRH (as induced by an estrogen challenge test). Five normal cycling women during the follicular phase of the cycle were used as control (FP group). Exogenous GnRH induced increments in the concentration of PRL, FSH and LH in PDUB and FP women. Increases were statistically higher for FSH (p less than 0.001) and LH (p less than 0.01), but not for PRL, in the FP group. No significant correlation was found between LH-PRL or FSH-PRL in PDUB women. A positive correlation was found when the maximal LH percent change for each case was compared with the simultaneous PRL percent value (r = 0.83, p less than 0.001) during the estrogen test. We conclude that, as shown by previous studies in both hypogonadal and normal women, also in this perimenopausal model exogenous GnRH induces secretion of PRL, LH and FSH, and that a positive correlation exists between LH and PRL under the finely modulated stimulation of gonadotrophs by endogenous GnRH.
对17名患有功能失调性子宫出血的围绝经期妇女（功能失调性子宫出血组）在接受外源性促性腺激素释放激素（GnRH）（静脉推注100微克剂量）刺激后以及内源性GnRH（由雌激素激发试验诱导）刺激后，检测其血清催乳素（PRL）、促黄体生成素（LH）和促卵泡生成素（FSH）的浓度。选取5名处于月经周期卵泡期的正常周期女性作为对照（卵泡期组）。外源性GnRH可使功能失调性子宫出血组和卵泡期组女性的PRL、FSH和LH浓度升高。卵泡期组中，FSH（p<0.001）和LH（p<0.01）的升高具有统计学意义，但PRL无统计学意义。功能失调性子宫出血组女性的LH-PRL或FSH-PRL之间未发现显著相关性。在雌激素试验期间，将每个病例的最大LH百分比变化与同时期的PRL百分比值进行比较时，发现存在正相关（r = 0.83，p<0.001）。我们得出结论，正如先前在性腺功能减退和正常女性中的研究所示，在这个围绝经期模型中，外源性GnRH也可诱导PRL、LH和FSH的分泌，并且在内源性GnRH对促性腺激素细胞的精细调节刺激下，LH和PRL之间存在正相关。
