Pd(II)催化的串联 C-H 芳基化/脱羧环化反应涉及环状二芳基碘鎓盐的二合一策略。
Two-in-One Strategy for the Pd(II)-Catalyzed Tandem C-H Arylation/Decarboxylative Annulation Involved with Cyclic Diaryliodonium Salts.
机构信息
College of Pharmaceutical Science , Zhejiang University of Technology , Hangzhou 310014 , P. R. China.
Institute of Information Resource , Zhejiang University of Technology , Hangzhou 310014 , P. R. China.
出版信息
Org Lett. 2019 Sep 20;21(18):7233-7237. doi: 10.1021/acs.orglett.9b02429. Epub 2019 Sep 3.
We report here a two-in-one strategy for the Pd(II)-catalyzed tandem C-H arylation/decarboxylative annulation between readily available cyclic diaryliodonium salts and benzoic acids. The carboxylic acid functionality can be used as both a directing group for the -C-H arylation and the reactive group for the tandem decarboxylative annulation. By a step-economical double cross-coupling annulation procedure, the privileged triphenylene frameworks were efficiently constructed, which have potential applications in material chemistry.
我们在此报告了一种 Pd(II)催化的串联 C-H 芳基化/脱羧环化反应的双功能策略，该策略涉及易得的环状二芳基碘鎓盐和苯甲酸。羧酸官能团既可以作为 -C-H 芳基化的导向基团，也可以作为串联脱羧环化反应的反应基团。通过经济高效的双交叉偶联环化程序，有效地构建了具有潜在应用价值的特权三联苯骨架。
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