College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Nojihigashi, Kusatsu Shiga, 525-8577, Japan.
Department of Chemistry, Faculty of Science, South Valley University, Qena 83523, Egypt.
Org Biomol Chem. 2022 Apr 20;20(16):3231-3248. doi: 10.1039/d1ob02501e.
Since the 1950s, diaryliodonium(III) salts have been demonstrated to participate in various arylation reactions, forming aryl-heteroatom and aryl-carbon bonds. Incorporating the arylation step into sequential transformations would provide access to complex molecules in short steps. This focus review summarizes the double functionalization of carbon-iodine(III) and carbon-hydrogen bonds using diaryliodonium(III) salts. This involves arylation/intramolecular rearrangement, arylation followed by electrophilic aromatic substitution, three-component [2 + 2 + 2] cascade annulation, sequential metal-catalyzed arylations, and double functionalization aryne formation.
自 20 世纪 50 年代以来，二芳基碘(III)盐已被证明可参与各种芳基化反应，形成芳基-杂原子和芳基-碳键。将芳基化步骤纳入连续转化中，可以短步骤获得复杂分子。本综述总结了使用二芳基碘(III)盐对碳-碘(III)和碳-氢键的双重官能化。这涉及芳基化/分子内重排、芳基化后亲电芳香取代、三组分[2+2+2]级联环化、顺序金属催化芳基化和双重官能化 芳炔形成。
