Department of Chemistry, Southern University of Science and Technology of China, Shenzhen, 518055, P. R. China.
Department of Biology, Southern University of Science and Technology of China, Shenzhen, 518055, P. R. China.
Chemistry. 2020 Jan 27;26(6):1166-1195. doi: 10.1002/chem.201903128. Epub 2019 Nov 19.
Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014-present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1, the most-studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.
布瑞他汀是一类具有独特快速发展临床应用前景的天然大环内酯类化合物，包括治疗艾滋病、老年痴呆症和癌症。本综述总结了布瑞他汀（2014 年至今）的最新研究进展，包括其全合成和生物医学应用。重点讨论了迄今为止研究最多的布瑞他汀 1 类似物。本文综述了布瑞他汀的合成和生物学挑战，并对其未来发展进行了展望。
