Department of Gastroenterology and Hepatology and Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands.
Department of Gastroenterology and Hepatology and Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands.
J Hepatol. 2019 Dec;71(6):1237-1245. doi: 10.1016/j.jhep.2019.08.020. Epub 2019 Aug 31.
The case of a 34-year-old woman with primary biliary cholangitis (PBC) before, during and after pregnancy is described. The use of ursodeoxycholic acid (UDCA) during and after pregnancy is discussed. UDCA has not been approved by the drug regulatory authorities as a pregnancy-safe drug; therefore, the reluctance of clinicians to prescribe UDCA during pregnancy is understandable. This Grand Round aims to provide a detailed analysis of the current evidence, safety data and clinical experience with UDCA (and alternative drugs) during pregnancy and lactation. Based on this analysis, advice for clinicians regarding the use of UDCA during pregnancy and lactation is given.
描述了一位 34 岁女性在怀孕前、怀孕期间和怀孕后的原发性胆汁性胆管炎（PBC）病例。讨论了在怀孕期间和怀孕后使用熊去氧胆酸（UDCA）的问题。UDCA 尚未被药品监管部门批准为妊娠安全药物；因此，临床医生不愿意在怀孕期间开UDCA 是可以理解的。本次大查房旨在对目前怀孕期间和哺乳期使用 UDCA（和替代药物）的证据、安全性数据和临床经验进行详细分析。基于这一分析，给出了临床医生在怀孕期间和哺乳期使用 UDCA 的建议。
