Department of Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.
Department of Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158518. doi: 10.1016/j.bbalip.2019.158518. Epub 2019 Aug 31.
Unhealthy Western-type diet and physical inactivity are highly associated with the current obesity epidemic and its related metabolic diseases such as atherosclerosis and non-alcoholic steatohepatitis. In addition, increasing evidence indicates that obesity is also a major risk factor for several types of common cancers. Recent studies have provided correlative support that disturbed lipid metabolism plays a role in cancer risk and development, pointing towards parallels in metabolic derangements between metabolic diseases and cancer. An important feature of disturbed lipid metabolism is the increase in circulating low-density lipoproteins, which can be oxidized (oxLDL). Elevated oxLDL and the level of its receptors have been positively associated with increased risk of various types of cancer. This review discusses the pro-oncogenic role of oxLDL in tumor development, progression and potential therapies, and provides insights into the underlying mechanisms.
不健康的西式饮食和缺乏运动与当前的肥胖症流行及其相关的代谢性疾病（如动脉粥样硬化和非酒精性脂肪性肝炎）密切相关。此外，越来越多的证据表明，肥胖也是多种常见癌症的主要危险因素。最近的研究提供了相关支持，表明脂质代谢紊乱在癌症风险和发展中起作用，这表明代谢紊乱在代谢性疾病和癌症之间存在相似之处。脂质代谢紊乱的一个重要特征是循环中低密度脂蛋白的增加，这种脂蛋白可以被氧化（oxLDL）。升高的 oxLDL 和其受体水平与各种类型癌症的风险增加呈正相关。这篇综述讨论了 oxLDL 在肿瘤发生、发展和潜在治疗中的致癌作用，并提供了对潜在机制的深入了解。
