Sawai Katsuji, Goi Takanori, Kimura Youhei, Koneri Kenji
First Department of Surgery, University of Fukui, Fukui 910-1193, Japan.
Cancers (Basel). 2024 Oct 21;16(20):3550. doi: 10.3390/cancers16203550.
Colorectal cancer is a major global health burden, with surgical resection being the standard treatment aimed at curative tumor removal. Oxidative stress plays a crucial role in colorectal cancer progression and prognosis. This study hypothesized that physical removal of colorectal cancer, a primary source of oxidative stress, would reduce blood levels of reactive oxygen metabolite derivatives (d-ROMs), a marker of oxidative stress, and biologic antioxidant potential (BAP) levels, a marker of antioxidant potential.
This study included 123 patients who underwent radical resection for colorectal cancer. d-ROM and BAP levels were measured before and one month after surgery.
The clinicopathological analysis showed a correlation between preoperative d-ROM levels and tumor size ( < 0.001). This study confirmed a significant reduction in d-ROM levels following tumor resection, indicating reduced systemic oxidative stress. The reduction was significant in stages II and III, but not in stage I. The d-ROM ratio before and after tumor resection was significantly higher in cases with positive lymph node metastasis and larger tumor size. BAP levels showed no significant changes post-surgery.
These results suggest that d-ROMs could serve as a valuable biomarker for monitoring tumor burden and surgical efficacy in patients with colorectal cancer.
结直肠癌是一项重大的全球健康负担，手术切除是旨在根治性切除肿瘤的标准治疗方法。氧化应激在结直肠癌的进展和预后中起着关键作用。本研究假设，作为氧化应激主要来源的结直肠癌的物理切除，将降低活性氧代谢物衍生物（d-ROMs，一种氧化应激标志物）的血液水平以及生物抗氧化潜力（BAP）水平（一种抗氧化潜力标志物）。
本研究纳入了123例行结直肠癌根治性切除术的患者。在手术前及术后1个月测量d-ROM和BAP水平。
临床病理分析显示术前d-ROM水平与肿瘤大小之间存在相关性（<0.001）。本研究证实肿瘤切除后d-ROM水平显著降低，表明全身氧化应激减轻。这种降低在II期和III期显著，但在I期不显著。肿瘤切除前后的d-ROM比值在淋巴结转移阳性和肿瘤体积较大的病例中显著更高。BAP水平术后无显著变化。
这些结果表明，d-ROMs可作为监测结直肠癌患者肿瘤负荷和手术疗效的有价值的生物标志物。
