ICMR-Regional Research Medical Centre, Gorakhpur, Uttar Pradesh, India.
ICMR-National Institute of Virology, Pune, Maharashtra, India.
J Neuroimmunol. 2019 Nov 15;336:577043. doi: 10.1016/j.jneuroim.2019.577043. Epub 2019 Aug 26.
TNFA, IL1B, HMGB1, IL10, CXCL8, CCL2 and CCR5 gene polymorphisms were investigated in 183 Japanese Encephalitis (JE) cases and 361 healthy controls from North India. Higher frequency of TNFA rs1800629 G/A, CCR5 rs1799987 genotypes with A allele and lower frequency of combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, andCCR5 rs1799987 A alleles and CCL2 rs1024611 G/G genotype was observed in JE cases. TNFA rs1800629 A and CCR5 rs1799987 A alleles were associated with susceptibility while combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, and rs1799987 A alleles and CCL2 rs1024611 G/G genotype was associated with protection to JE.
在印度北部，研究了 183 例日本脑炎（JE）病例和 361 例健康对照者的 TNFA、IL1B、HMGB1、IL10、CXCL8、CCL2 和 CCR5 基因多态性。在 JE 病例中，观察到 TNFA rs1800629 G/A、CCR5 rs1799987 基因型具有 A 等位基因和缺乏 TNFA rs1800629 A、CCR5 rs333 Δ32 和 CCR5 rs1799987 A 等位基因以及 CCL2 rs1024611 G/G 基因型的频率较高。TNFA rs1800629 A 和 CCR5 rs1799987 A 等位基因与易感性相关，而缺乏 TNFA rs1800629 A、CCR5 rs333 Δ32 和 rs1799987 A 等位基因以及 CCL2 rs1024611 G/G 基因型的组合与 JE 的保护相关。
