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三尖杉茎中的紫檀烷及其对胰脂肪酶和脂肪积累的抑制作用。

Xanthones from the stems of Cudrania tricuspidata and their inhibitory effects on pancreatic lipase and fat accumulation.

机构信息

College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, Republic of Korea.

出版信息

Bioorg Chem. 2019 Nov;92:103234. doi: 10.1016/j.bioorg.2019.103234. Epub 2019 Aug 29.

DOI:10.1016/j.bioorg.2019.103234

PMID:31479985

Abstract

Nine new xanthones, cudracuspixanthones I - Q (12-14, 25, 32-36), and 30 known xanthones (1-11, 15-24, 26-31, 37-39) were isolated from the stems of Cudrania tricuspidata (Moraceae). The structures of isolated compounds were established by using 1D and 2D NMR in combination with HR-TOF-MS. Xanthones from the stems of C. tricuspidata exerted pancreatic lipase inhibitory activity. In addition, cudracuspixanthone P (35), a new xanthone, reduced the fat accumulation in liver cells stimulated with fatty acids. Therefore, these compounds might be beneficial in the treatment of metabolic diseases.

摘要

从三叶木通（Moraceae）茎中分离得到了 9 个新的紫檀烷酮，即 cudracuspixanthones I-Q（12-14、25、32-36）和 30 个已知的紫檀烷酮（1-11、15-24、26-31、37-39）。通过使用 1D 和 2D NMR 结合 HR-TOF-MS，确定了分离化合物的结构。来自三叶木通茎的紫檀烷酮具有胰腺脂肪酶抑制活性。此外，新紫檀烷酮 cudracuspixanthone P（35）可减少脂肪酸刺激的肝细胞脂肪堆积。因此，这些化合物可能有益于代谢疾病的治疗。