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克唑替尼相关性肾囊在间变性淋巴瘤激酶阳性肺癌患者中的作用：单中心经验。

Crizotinib-Associated Renal Cysts in Anaplastic Lymphoma Kinase-Positive Lung Cancer Patients: A Single-Center Experience.

机构信息

Medical Oncology Unit, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Urol Int. 2020;104(3-4):269-272. doi: 10.1159/000502664. Epub 2019 Sep 3.

DOI:10.1159/000502664
PMID:31480046
Abstract

Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor that was approved for ALK-harboring lung cancer. There have been reports about the development and progression of renal cysts from crizotinib. We report a series of 3 cases of crizotinib-associated renal cysts in patients admitted to our institution, with different kinds of presentation. A monitor for complex renal cysts is warranted in patients receiving crizotinib.

摘要

克唑替尼是一种间变性淋巴瘤激酶 (ALK) 抑制剂，已被批准用于治疗含有 ALK 的肺癌。已有报道称，克唑替尼可导致肾囊肿的发生和进展。我们报告了 3 例在我院就诊的克唑替尼相关肾囊肿患者，他们的临床表现各不相同。接受克唑替尼治疗的患者需要对复杂肾囊肿进行监测。

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引用本文的文献

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Development of crizotinib-associated renal cyst in a non-small cell lung cancer patient with ALK fusion: a case report and review of the literature.一例ALK融合的非小细胞肺癌患者发生克唑替尼相关肾囊肿：病例报告及文献复习
Diagn Pathol. 2024 Apr 14;19(1):58. doi: 10.1186/s13000-024-01480-7.
2
Renal Abscess Caused by Crizotinib: A Rare Case Report.克唑替尼引起的肾脓肿：一例罕见病例报告
Front Oncol. 2022 Jul 7;12:920990. doi: 10.3389/fonc.2022.920990. eCollection 2022.