在未刺激的体外受精周期中，除人绒毛膜促性腺激素外，在卵泡中期添加促卵泡生成素以确定卵泡抽吸时机的效用。

The utility of a midcycle follicle-stimulating hormone boost in addition to human chorionic gonadotropin for timing of follicle aspiration in unstimulated in vitro fertilization cycles.

作者信息

Lindheim S R, Sauer M V, Francis M M, Macaso T, Lobo R, Paulson R J

机构信息

Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles, USA.

出版信息

Gynecol Obstet Invest. 1997;43(2):76-8. doi: 10.1159/000291825.

DOI:10.1159/000291825

PMID:9067710

Abstract

PURPOSE

To analyze the effects and potential benefits of a single midcycle dose of follicle-stimulating hormone (FSH) prior to human chorionic gonadotropin (hCG) administration during unstimulated in vitro fertilization (IVF) cycles.

METHODS

Twenty-five cycles from 20 patients receiving 150 IU of FSH 42-44 h and 10,000 IU of hCG 34-36 h prior to follicle aspiration were compared to 110 cycles triggered with hCG alone.

RESULTS

Serum E2 levels were significantly lower on the day of hCG treatment in the FSH-treated group (266 vs. 297 pg/ml). On the day after hCG administration, serum E2 was similar in both groups. Maximum follicular diameters the day of and the day after hCG treatment were similar as were the number of oocytes aspirated and embryos transferred, and clinical pregnancy rates in both groups. The number of cycles dropped due to premature luteinizing-hormone (LH) surge was 8% in the FSH group compared to 20% in the group treated with hCG alone.

CONCLUSIONS

A midcycle FSH boost does not increase pregnancy success of unstimulated IVF cycles but does enhance the increase in serum E2 levels after hCG, thereby potentially allowing earlier hCG administration while incurring decreased cycle cancellation rates due to premature LH surges.

摘要

目的

分析在未刺激的体外受精（IVF）周期中，在注射人绒毛膜促性腺激素（hCG）之前单次给予卵泡刺激素（FSH）的中期剂量的效果和潜在益处。

方法

将20例患者的25个周期与仅用hCG触发的110个周期进行比较，这些患者在卵泡抽吸前42 - 44小时接受150 IU的FSH，在卵泡抽吸前34 - 36小时接受10000 IU的hCG。

结果

FSH治疗组在hCG治疗当天的血清E2水平显著较低（266 vs. 297 pg/ml）。在注射hCG后的第二天，两组的血清E2水平相似。hCG治疗当天和第二天的最大卵泡直径、吸出的卵母细胞数量、移植的胚胎数量以及两组的临床妊娠率相似。因促黄体生成素（LH）过早激增而取消的周期数在FSH组为8%，而仅用hCG治疗的组为20%。