核肌动蛋白丝在 DNA 修复动力学中的作用。
Nuclear actin filaments in DNA repair dynamics.
机构信息
Molecular and Computational Biology Department, University of Southern California, Los Angeles, CA, USA.
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Freiburg im Breisgau, Germany.
出版信息
Nat Cell Biol. 2019 Sep;21(9):1068-1077. doi: 10.1038/s41556-019-0379-1. Epub 2019 Sep 3.
Abstract
Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled the detection of surprising nuclear structures responding to various stimuli, challenging previous models that actin is substantially monomeric in the nucleus. We review these discoveries, focusing on double-strand break (DSB) repair responses. These studies revealed a remarkable network of nuclear filaments and regulatory mechanisms coordinating chromatin dynamics with repair progression and led to a paradigm shift by uncovering the directed movement of repair sites.
摘要
近年来，用于活细胞肌动蛋白丝（F-actin）成像的创新工具的发展，使得人们能够检测到各种刺激下出人意料的核结构，这对肌动蛋白在核内主要以单体形式存在的先前模型提出了挑战。我们综述了这些发现，重点介绍了双链断裂（DSB）修复反应。这些研究揭示了核丝的惊人网络和调节机制，协调了染色质动力学与修复进程，并通过揭示修复位点的定向运动，带来了范式转变。
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