Szabó Anikó, Borkúti Péter, Kovács Zoltán, Kristó Ildikó, Vilmos Péter
HUN-REN Biological Research Centre, Institute of Genetics, Szeged, Hungary.
Nucleus. 2025 Dec;16(1):2498643. doi: 10.1080/19491034.2025.2498643. Epub 2025 May 4.
Actin was first observed in the nucleus more than sixty years ago but research on nuclear actin did not receive significant attention for the next forty years. It only started to accelerate around the year 2000, when the first convincing experimental data emerged indicating that actin participates in essential nuclear processes. Today, we know that actin is involved in transcription, replication, DNA repair, chromatin remodeling, and participates in the determination of nuclear shape and size. In this paper we review the results of the last five years of increasingly intensive research on nuclear actin, because on one hand, the field has expanded with several new directions during this time, and on the other hand, the enrichment of our picture of nuclear actin will certainly provide a more solid foundation and new impetus for its future investigation.
六十多年前，肌动蛋白首次在细胞核中被观察到，但在接下来的四十年里，关于细胞核肌动蛋白的研究并未受到太多关注。直到2000年左右，随着第一批有说服力的实验数据出现，表明肌动蛋白参与了细胞核的重要过程，相关研究才开始加速。如今，我们知道肌动蛋白参与转录、复制、DNA修复、染色质重塑，并在细胞核形状和大小的确定中发挥作用。在本文中，我们回顾了过去五年对细胞核肌动蛋白日益深入的研究成果，一方面是因为在此期间该领域在几个新方向上得到了拓展，另一方面是因为我们对细胞核肌动蛋白认识的丰富，肯定会为其未来的研究提供更坚实的基础和新的动力。
