Doslak M J, Dell'Osso L F, Daroff R B
Biol Cybern. 1979 Oct;34(3):181-6. doi: 10.1007/BF00336969.
The observation that the amplitude of vestibular nystagmus grows as gaze is increased in the direction of the nystagmus fast phase and diminished with gaze in the opposite direction is known as "Alexander's law". We have developed an analog computer model to simulate Alexander's law in nystagmus secondary to dysfunction of a semicircular canal. The model utilizes relevant brainstem anatomy and physiology and includes gaze modulation of vestibular signals and push-pull integration to create eye position commands. When simulating normally functioning semicircular canals, the model produced no nystagmus. When simulating total impairment of the canal on one side with gaze directed maximally in the opposite direction, the model produced a large amplitude nystagmus with linear slow phases directed toward the affected side. As gaze was changed from far contralateral to ipsilateral, the nystagmus gradually diminished to zero. When simulating partial impairment of one canal, the nystagmus was smaller in amplitude and absent in ipsilateral gaze.
在前庭眼震快相方向上，随着注视角度增加，前庭眼震的幅度增大；而在相反方向注视时，前庭眼震的幅度减小，这一现象被称为“亚历山大定律”。我们开发了一个模拟计算机模型，以模拟继发于半规管功能障碍的眼震中的亚历山大定律。该模型利用了相关的脑干解剖结构和生理学知识，包括前庭信号的注视调制和推挽整合，以生成眼位指令。在模拟正常功能的半规管时，该模型未产生眼震。当模拟一侧半规管完全受损且注视方向最大程度地偏向对侧时，该模型产生了一个大幅度眼震，其线性慢相指向患侧。当注视方向从远对侧变为同侧时，眼震逐渐减小至零。当模拟一侧半规管部分受损时，眼震幅度较小，且在同侧注视时不存在。
