University of Manitoba, Winnipeg, Canada; Cerebra Health Inc., Winnipeg, Canada; RANA Respiratory Care Group, Brandon, Manitoba.
Cerebra Health Inc., Winnipeg, Canada.
J Clin Sleep Med. 2019 Aug 15;15(8):1155-1163. doi: 10.5664/jcsm.7812.
The Odds Ratio Product (ORP) is an objective measure of sleep depth using the relationships of the powers of different electroencephalogram (EEG) frequencies in a single index. The range of the ORP is 0 (deeply asleep) to 2.5 (fully awake). This investigation seeks to elucidate normal values of non-rapid eye movement ORP (ORP) in healthy individuals, repeatability of the measure, and the change in ORP following continuous positive airway pressure (CPAP) treatment.
Healthy individuals underwent a home sleep apnea test (HSAT) with EEG followed 1 week later by EEG alone. Another cohort with OSA underwent baseline HSAT with EEG followed by a second EEG study approximately 4 weeks into treatment with CPAP.
Thirty-eight healthy individuals completed the protocol (mean age of 34.9 ± 7.4 years, Epworth Sleepiness Scale score 3.6 ± 2.4, Insomnia Severity Index score 2.0 ± 1.6 and Functional Outcomes of Sleep Questionnaire - shorter version score 19 ± 1.2). The mean ORP for all nights was 0.52 ± 0.13. The difference between the first night and the second night was 0.024 ± 0.17 (not significant). The intraclass correlation coefficient was 0.525, suggesting only moderate agreement between the first and second nights. The normal value for ORP in healthy individuals is ≤ 0.78 units using two standard deviations as the cutoff. Forty participants completed the OSA protocol (mean age 49 ± 11 years, body mass index 35 ± 6 kg/m², apnea-hypopnea index 33.5 ± 28.4 events/h). The mean pre-CPAP ORP was 0.69 ± 0.24 and the mean post-CPAP ORP was 0.57 ± 0.22 (P = .02).
The ORP proves to have significant variability from night to night in healthy individuals. ORP objectively improves following CPAP treatment, providing further evidence that it measures sleep depth.
Penner CG, Gerardy B, Ryan R, Williams M. The odds ratio product (an objective sleep depth measure): normal values, repeatability, and change with CPAP in patients with OSA. J Clin Sleep Med. 2019;15(8):1155-1163.
使用不同脑电（EEG）频率的幂次之间的关系，比值乘积（ORP）是一种客观的睡眠深度测量方法。ORP 的范围为 0（深度睡眠）至 2.5（完全清醒）。本研究旨在阐明健康个体的非快速眼动期 ORP（ORP）的正常值、该测量方法的可重复性，以及持续气道正压通气（CPAP）治疗后 ORP 的变化。
健康个体进行家庭睡眠呼吸暂停测试（HSAT），并进行脑电图检查，一周后仅进行脑电图检查。另一组 OSA 患者进行基线 HSAT 和脑电图检查，然后在 CPAP 治疗约 4 周后进行第二次脑电图研究。
38 名健康个体完成了该方案（平均年龄 34.9±7.4 岁，Epworth 睡眠量表评分为 3.6±2.4，失眠严重程度指数评分为 2.0±1.6，睡眠功能结果简短版问卷评分为 19±1.2）。所有夜间的平均 ORP 为 0.52±0.13。第一晚和第二晚之间的差异为 0.024±0.17（无统计学意义）。组内相关系数为 0.525，表明第一晚和第二晚之间的一致性仅为中等。使用两个标准差作为截止值，健康个体的 ORP 正常值为≤0.78 个单位。40 名参与者完成了 OSA 方案（平均年龄 49±11 岁，体重指数 35±6kg/m²，呼吸暂停-低通气指数 33.5±28.4 次/小时）。CPAP 治疗前的平均 ORP 为 0.69±0.24，CPAP 治疗后的平均 ORP 为 0.57±0.22（P=0.02）。
ORP 在健康个体中存在显著的夜间变异性。CPAP 治疗后 ORP 客观改善，进一步证明其测量睡眠深度。
Penner CG, Gerardy B, Ryan R, Williams M. The odds ratio product (an objective sleep depth measure): normal values, repeatability, and change with CPAP in patients with OSA. J Clin Sleep Med. 2019;15(8):1155-1163.
