椎间盘退变患者血清中的炎症生物标志物。
Inflammatory biomarkers in sera of patients with intervertebral disc degeneration.
作者信息
Rodrigues Luciano Miller Reis, Oliveira Lilian Zerbinatti de, Silva Mariane de Barros Ribeiro da, Accardo Camila de Melo, Giglio Adriana Braz Del, Pinhal Maria Aparecida da Silva
机构信息
Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Universidade Federal de São Paulo, São Paulo, SP, Brazil.
出版信息
Einstein (Sao Paulo). 2019 Aug 29;17(4):eAO4637. doi: 10.31744/einstein_journal/2019AO4637.
OBJECTIVE
To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers.
METHODS
We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration patients, fracture patients, and healthy individuals.
RESULTS
Interleukin 6 and cathepsin B seem to be related with physiopathology of intervertebral disc degeneration, since the levels of both were higher in discs of patients with intervertebral disc degeneration. Interleukin 6 and cathepsin B do not represent good biomarkers of degenerative intervertebral disc disease, since the level of such compounds is increased in the plasma of patients with fractures.
CONCLUSION
Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.
目的
评估患有退行性疾病患者椎间盘炎症因子（白细胞介素6）水平和蛋白酶活性（组织蛋白酶B），以及血清白细胞介素6水平、血清组织蛋白酶B活性和透明质酸生物标志物。
方法
我们对椎间盘进行免疫组织化学研究，以分析患有退行性疾病和脊柱骨折患者（对照组）的白细胞介素6和组织蛋白酶B水平，并测量椎间盘退变患者、骨折患者和健康个体血清中的透明质酸、白细胞介素6和组织蛋白酶B活性。
结果
白细胞介素6和组织蛋白酶B似乎与椎间盘退变的病理生理学相关，因为在椎间盘退变患者的椎间盘中二者水平均较高。白细胞介素6和组织蛋白酶B并非退行性椎间盘疾病的良好生物标志物，因为此类化合物水平在骨折患者血浆中也会升高。
结论
透明质酸可以作为椎间盘退变的生物标志物,因为仅在椎间盘退变患者的血清中透明质酸水平较高。
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