Machado Lilian F, Kawamuro Mariana, Portela Renata C, Fares Nikoly T, Bergamo Vinicius, Souza Leonardo M de, Paranhos Augusto, Prata Tiago S, Gracitelli Carolina P B
Department of Ophthalmology and Vision Science, Glaucoma Service, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Glaucoma Sector, Ver Mais Oftalmologia, Vinhedo, SP, Brazil.
Arq Bras Oftalmol. 2019 Aug 29;82(6):463-470. doi: 10.5935/0004-2749.20190089. eCollection 2019.
To evaluate the impact of visual acuity, visual field damage, and other factors on the quality of life in Brazilian patients with glaucoma.
This cross-sectional prospective study involved 49 patients with glaucoma enrolled based on the presence of reproducible standard automated perimetry defects in at least one eye at the time of evaluation. A detailed ophthalmologic examination was performed on each patient. All patients had reproducible standard automated perimetry and completed an NEI VFQ-25 questionnaire. The associations of the quality of life scores to the best-corrected visual acuity and the visual field loss of the better and worse eyes were investigated.
The mean quality of life score of the patients was 58.8 ± 18.7 units. The highest and lowest mean values (85.0 ± 24.2 and 37.5 ± 36.5 units) were observed in the "Social Functioning Subscale" and "Driving Subscale," respectively. Patients with advanced glaucoma (mean deviation <-12 dB) in the worse eye had significantly lower quality of life scores (p=0.007). There was a significant correlation between the quality of life scores and the visual acuity of the better and worse eyes (r2=13%, p=0.010 and r2=32%, p<0.001, respectively). There was also a significant correlation between the quality of life scores and standard automated perimetry mean deviation of the better and worse eyes (r2=13%, p=0.023 and r2=47%, p<0.001, respectively). In a multivariate model containing so-cioeconomic and comorbidity indices, quality of life remained significantly related to the standard automated perimetry mean deviation of the better and worse eyes (r2=23%, p=0.29 and r2=49%, p<0.001, respectively) as well as to the visual acuity of the better and worse eyes (r2=18%, p=0.017 and r2=40%, p<0.001, respectively).
The standard automated perimetry mean deviation and the visual acuity of the better and worse eyes were associated with lower quality of life in Brazilian patients with glaucoma. Quality of life was mostly highly associated with the standard automated perimetry mean deviation of the worse eye.
评估视力、视野损害及其他因素对巴西青光眼患者生活质量的影响。
这项横断面前瞻性研究纳入了49例青光眼患者，入选标准为在评估时至少一只眼睛存在可重复的标准自动视野计缺陷。对每位患者进行了详细的眼科检查。所有患者均进行了可重复的标准自动视野计检查，并完成了NEI VFQ - 25问卷。研究了生活质量得分与最佳矫正视力以及较好和较差眼睛的视野损失之间的关联。
患者的平均生活质量得分为58.8±18.7分。在“社会功能子量表”和“驾驶子量表”中分别观察到最高和最低平均值（85.0±24.2分和37.5±36.5分）。较差眼睛患有晚期青光眼（平均偏差<-12 dB）的患者生活质量得分显著较低（p = 0.007）。生活质量得分与较好和较差眼睛的视力之间存在显著相关性（r2分别为13%，p = 0.010和r2为32%，p<0.001）。生活质量得分与较好和较差眼睛的标准自动视野计平均偏差之间也存在显著相关性（r2分别为13%，p = 0.023和r2为47%，p<0.001）。在包含社会经济和合并症指数的多变量模型中，生活质量仍然与较好和较差眼睛的标准自动视野计平均偏差显著相关（r2分别为23%，p = 0.29和r2为49%，p<0.001），以及与较好和较差眼睛的视力显著相关（r2分别为18%，p = 0.017和r2为40%，p<0.001）。
较好和较差眼睛的标准自动视野计平均偏差以及视力与巴西青光眼患者较低的生活质量相关。生活质量大多与较差眼睛的标准自动视野计平均偏差高度相关。
