J Clin Invest. 2019 Oct 1;129(10):4080-4082. doi: 10.1172/JCI131649.
Recent work demonstrated a role for myeloid-derived suppressor cells (MDSCs) in the antimicrobial response in newborns, but the signals guiding their differentiation remained unknown. In this issue of the JCI, Liu et al. demonstrate that lactoferrin (LF) converts newborn neutrophils and monocytes to MDSCs via the low-density lipoprotein receptor-related protein-2 (LRP2) receptor and NF-κB activation. Due to their strong antimicrobial activity, adoptive transfer of MDSCs generated by in vitro culture with LF prolonged the survival of newborn mice with necrotizing enterocolitis, a severe pathology in preterm infants. These findings indicate a surprising protective role of MDSCs in newborns and demonstrate the potential of MDSC therapy for the treatment of infants with diseases associated with deregulated inflammation.
最近的研究表明，髓系来源的抑制细胞（MDSCs）在新生儿的抗菌反应中起作用，但指导其分化的信号仍然未知。在本期 JCI 中，刘等人表明乳铁蛋白（LF）通过低密度脂蛋白受体相关蛋白-2（LRP2）受体和 NF-κB 激活将新生中性粒细胞和单核细胞转化为 MDSCs。由于它们具有很强的抗菌活性，通过体外培养用 LF 生成的 MDSC 的过继转移延长了患有坏死性小肠结肠炎的新生小鼠的存活时间，坏死性小肠结肠炎是早产儿的一种严重疾病。这些发现表明 MDSCs 在新生儿中具有惊人的保护作用，并表明 MDSC 疗法治疗与炎症失调相关疾病的婴儿的潜力。
