Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany.
Integrative Model-Based Cognitive Neuroscience Research Unit, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Mov Disord. 2019 Nov;34(11):1734-1739. doi: 10.1002/mds.27838. Epub 2019 Sep 4.
This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months.
Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1-T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3-12 Hz) and beta range (13-30 Hz).
A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3-12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3-7.5), but not beta activity (13-30 Hz) was revealed within participants across timepoints.
Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. © 2019 International Parkinson and Movement Disorder Society.
本研究调查了慢性深部脑刺激数月后，在弛缓期内，苍白球低频活动与肌张力障碍运动症状严重程度之间的关系。
在 9 例肌张力障碍患者的 5 个时间点（T1-T5）期间，记录局部场电位，同时使用 Burke-Fahn-Marsden 肌张力障碍评定量表进行临床评估。采用线性混合效应模型，探讨运动症状与低频（3-12 Hz）和β频带（13-30 Hz）局部场电位活动之间的潜在关联。
在跨时间点的参与者中，Burke-Fahn-Marsden 肌张力障碍评定量表评分与低频活动（3-12 Hz；b=4.4；标准误差=1.5，自由度=43，P=0.006，95%置信区间，1.3-7.5）呈显著相关，但与β活动（13-30 Hz）无关。
低频活动与肌张力障碍运动症状的严重程度有关，即使在慢性深部脑刺激数月后也是如此。我们的发现证实了低频活动在肌张力障碍中的病理生理作用，并强调了其作为适应性神经调节生物标志物的潜在效用。国际帕金森病和运动障碍协会 2019 年。
