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纤维化与癌症的关联：机制与治疗挑战。

Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges.

机构信息

Department of Nephrology, Wenzhou Medical University, Wenzhou 317000, China.

Department of Immunology, Mie University School of Medicine, Edobashi 2-174, Tsu-city, Mie 514-8507, Japan.

出版信息

Int J Mol Sci. 2019 Sep 3;20(17):4313. doi: 10.3390/ijms20174313.

DOI:10.3390/ijms20174313
PMID:31484418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6747394/
Abstract

Fibrosis is the end-stage of chronic inflammatory diseases and tissue damage resulting from a dysregulated wound-healing response [...].

摘要

纤维化是慢性炎症性疾病和组织损伤的终末期，是由于失调的伤口愈合反应引起的[...]。

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Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes.二十二碳六烯酸通过 G 蛋白偶联受体 40 抑制原代肝细胞固醇调节元件结合蛋白 1 介导的脂肪生成酶表达。
Int J Mol Sci. 2019 May 28;20(11):2625. doi: 10.3390/ijms20112625.
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Common Pathogenic Mechanisms Between Idiopathic Pulmonary Fibrosis and Lung Cancer.特发性肺纤维化和肺癌之间的共同发病机制。
Chest. 2019 Aug;156(2):383-391. doi: 10.1016/j.chest.2019.04.114. Epub 2019 May 22.
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Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis.肝星状细胞在肝纤维化和癌变过程中的激活中的表观遗传机制。
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Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment.癌症相关成纤维细胞构建并稳固肿瘤微环境。
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Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies.活化的成纤维细胞程序调控肿瘤的起始和进展；分子机制和相关的治疗策略。
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