Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
J Pathol. 2013 Jan;229(2):157-67. doi: 10.1002/path.4116.
Inflammasome signalling and downstream cytokine responses mediated by the inflammasome have been found to play an important role, not only in wound healing but also in fibrosis. The inflammasome regulates the secretion of IL-1β and IL-18 cytokines, and both are critical for the repair of damaged tissue and play a role in fibrosis. However, what dictates the fine balance between normal wound healing versus fibrosis is yet to be fully elucidated. Further investigations into the role of the inflammasomes in these pathologies will be important for the discovery of novel therapeutics that can abrogate fibrosis or promote wound healing in chronic disease.
炎症小体信号及其下游细胞因子反应被发现不仅在伤口愈合中，而且在纤维化中都发挥着重要作用。炎症小体调节 IL-1β 和 IL-18 细胞因子的分泌，两者对于受损组织的修复至关重要，并在纤维化中发挥作用。然而，决定正常伤口愈合与纤维化之间精细平衡的因素尚未完全阐明。进一步研究炎症小体在这些病理中的作用对于发现可以消除纤维化或促进慢性疾病伤口愈合的新型治疗方法将是重要的。
