初潮年龄与儿童期后代体重指数。

Maternal age at menarche and offspring body mass index in childhood.

机构信息

MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.

Child Health Advocacy Institute, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

出版信息

BMC Pediatr. 2019 Sep 4;19(1):312. doi: 10.1186/s12887-019-1659-4.

DOI:10.1186/s12887-019-1659-4

PMID:31484496

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6724332/

Abstract

BACKGROUND

Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear.

METHODS

In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI.

RESULTS

A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associated with higher child BMI in boys (- 0.05 z-score per year older MAM, 95% CI - 0.08 to - 0.02) and in girls (- 0.05 z-score per year older MAM, 95% CI - 0.07 to - 0.02). Maternal BMI positively mediated the association of MAM with offspring BMI in both sexes, with mediation effects of 37.7 and 19.4% for boys and girls, respectively.

CONCLUSION

Early maternal menarche was associated with greater offspring BMI. This study provides evidence for the intergenerational effect in the development of BMI in offspring.

摘要

背景

初潮年龄较早与成年后患慢性病的风险增加有关，但初潮较早是否具有代际效应尚不清楚。

方法

在这项基于人群的横断面研究中，我们于 2014 年在中国上海的 26 所小学使用整群随机概率抽样方法招募了儿童。我们使用多元线性回归模型来估计母亲初潮年龄（MAM）与后代体重指数（BMI）的调整关联。我们还使用中介分析来检验母亲 BMI 和妊娠期糖尿病对后代 BMI 的贡献。

结果

共纳入 17571 名 6-13 岁的儿童，其中 16373 名儿童测量了体重和身高。母亲初潮年龄较早与男孩（每增加 1 岁，BMI 增加 0.05z 评分，95%置信区间为 0.08 至 0.02）和女孩（每增加 1 岁，BMI 增加 0.05z 评分，95%置信区间为 0.07 至 0.02）的后代 BMI 较高有关。母亲 BMI 正向中介了 MAM 与后代 BMI 之间的关联，对男孩和女孩的中介效应分别为 37.7%和 19.4%。