LMO2 阴性和 CD38 阳性的组合对 Burkitt 淋巴瘤的诊断有用。
A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
机构信息
Department of Pathology, Affiliated Hospital of Nantong University, Nantong, 226001, People's Republic of China.
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100000, People's Republic of China.
出版信息
Diagn Pathol. 2019 Sep 4;14(1):100. doi: 10.1186/s13000-019-0876-3.
BACKGROUND
To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL).
METHODS
LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration.
RESULTS
The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone.
CONCLUSIONS
A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
背景
评估 LIM 结构域只有 2 （LMO2）阴性和 CD38 阳性在诊断伯基特淋巴瘤（BL）中的临床效用。
方法
通过免疫组织化学方法在 75 例 BL、12 例高级别 B 细胞淋巴瘤、NOS（HGBL，NOS）和 3 例具有 11q 异常的伯基特样淋巴瘤中检测 LMO2 和 CD38 的表达。
结果
LMO2 阴性检测 BL 的敏感性和特异性分别为 98.67%和 100%；CD38 阳性检测 BL 的敏感性和特异性分别为 98.67%和 66.67%。两者联合检测 BL 的敏感性和特异性分别为 97.33%和 100%。在本研究中，LMO2 阴性和 CD38 阳性的联合结果比单独的 LMO2 阴性或 CD38 阳性具有更高的曲线下面积。
结论
LMO2 阴性和 CD38 阳性的联合检测对诊断伯基特淋巴瘤是有用的。
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