Li Qi, Yang Jun, Yang Jian, Yang Ying
Department of Cardiology,Institute of Cardiovascular Diseases,the First College of Clinical Medical Sciences,China Three Gorges University,Yichang,Hubei 443002,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Aug 30;41(4):536-540. doi: 10.3881/j.issn.1000-503X.10900.
Apoptosis plays important roles in maintaining normal development and homeostasis and in the pathophysiological processes of various diseases.Previous studies have shown that cardiomyocyte apoptosis is involved in the development of various cardiovascular diseases.The apoptosis repressor with caspase recruitment domain(ARC)is abundantly expressed in heart,which makes ARC a unique and central cardioprotective factor via anti-apoptotic pathway.This article reviews the structure and characteristics of ARC as well as the roles and mechanisms of ARC in cardiovascular diseases.
细胞凋亡在维持正常发育和体内平衡以及各种疾病的病理生理过程中发挥着重要作用。先前的研究表明，心肌细胞凋亡参与了各种心血管疾病的发生发展。含半胱天冬酶募集结构域的凋亡抑制因子（ARC）在心脏中大量表达，这使得ARC通过抗凋亡途径成为一种独特且核心的心脏保护因子。本文综述了ARC的结构和特性，以及ARC在心血管疾病中的作用和机制。
