Department of Immunology, Zunyi Medical University, 563000, Zunyi, China.
Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, 563000, Zunyi, China.
Apoptosis. 2023 Apr;28(3-4):313-325. doi: 10.1007/s10495-022-01802-4. Epub 2023 Jan 18.
Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the powerful inhibition of apoptosis, ARC is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (I/R) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. However, recent studies have found that ARC also plays a potential regulatory role in tumorigenesis especially in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways, which remains to be explored in further studies. Therefore, ARC regulates the body and maintains the balance of physiological activities with its interesting duplex. This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers.
凋亡抑制因子 with caspase recruitment domain (ARC) 作为一种有效的多功能凋亡抑制剂，主要在有丝分裂后的细胞中表达，包括心肌细胞。ARC 的特殊之处在于其 N 端的 caspase 募集结构域和 caspase 募集结构域。由于对凋亡的强大抑制作用，ARC 主要被报道在缺血再灌注（I/R）损伤期间作为一种心脏保护因子，防止心肌细胞受到各种灾难的破坏，包括氧化应激、钙超载和线粒体功能障碍在循环系统中。然而，最近的研究发现，ARC 也通过多种与凋亡相关的途径在肿瘤发生中发挥潜在的调节作用，特别是在结直肠癌和肾细胞癌中，这仍有待进一步研究。因此，ARC 通过其有趣的双螺旋结构调节身体并维持生理活动的平衡。这篇综述总结了 ARC 在肿瘤发生和缺血/再灌注损伤领域的研究进展，为研究人员提供了全面的研究现状和新的可能性。
