Nabeshima T, Tohyama K, Kameyama T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Eur J Pharmacol. 1988 Oct 18;155(3):211-7. doi: 10.1016/0014-2999(88)90506-7.
We investigated the effects of benzodiazepine inverse agonists on ethanol-induced amnesia using a passive avoidance task. Pretraining treatment of mice with ethanol significantly impaired the passive avoidance response: there was a significant reduction in the % retention and step-down latency. The benzodiazepine inverse agonists, Ro 15-4513 and beta-CCM, significantly increased the % retention and prolonged the step-down latencies in mice treated with ethanol, but FG 7142 did not. The anti-amnesic effects of Ro 15-4513 were completely antagonized by co-administration of Ro 15-1788, a benzodiazepine antagonist. These results suggest that the anti-amnesic effect of Ro 15-4513 on alcohol-induced amnesia is mediated by benzodiazepine receptors.
我们使用被动回避任务研究了苯二氮䓬反向激动剂对乙醇诱导失忆的影响。用乙醇对小鼠进行预训练处理显著损害了被动回避反应：记忆保持率和跳下潜伏期显著降低。苯二氮䓬反向激动剂Ro 15 - 4513和β-CCM显著提高了用乙醇处理的小鼠的记忆保持率并延长了跳下潜伏期，但FG 7142没有此作用。Ro 15 - 4513的抗失忆作用被苯二氮䓬拮抗剂Ro 15 - 1788共同给药完全拮抗。这些结果表明，Ro 15 - 4513对酒精诱导失忆的抗失忆作用是由苯二氮䓬受体介导的。
