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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18808-18814. doi: 10.1073/pnas.1909972116. Epub 2019 Sep 4.
2
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.
Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2208540119. doi: 10.1073/pnas.2208540119. Epub 2022 Sep 7.
3
Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors.
J Enzyme Inhib Med Chem. 2017 Dec;32(1):821-831. doi: 10.1080/14756366.2017.1326915.
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1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.
Bioorg Med Chem. 2018 Nov 15;26(21):5583-5595. doi: 10.1016/j.bmc.2018.09.034. Epub 2018 Sep 27.
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A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.
Angew Chem Int Ed Engl. 2016 Nov 2;55(45):14155-14158. doi: 10.1002/anie.201608807. Epub 2016 Oct 10.
6
Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides.
Bioorg Med Chem. 2008 Jan 15;16(2):692-8. doi: 10.1016/j.bmc.2007.10.041. Epub 2007 Oct 18.
8
Sulfur-fluoride exchange (SuFEx)-enabled lead discovery of AChE inhibitors by fragment linking strategies.
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9
1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.
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Structure-based rational design of covalent probes.
Commun Chem. 2025 Aug 12;8(1):242. doi: 10.1038/s42004-025-01606-y.
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Advances in sulfonyl exchange chemical biology: expanding druggable target space.
Chem Sci. 2025 May 6;16(23):10119-10140. doi: 10.1039/d5sc02647d. eCollection 2025 Jun 11.
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Mimicry of molecular glues using dual covalent chimeras.
Nat Commun. 2025 Mar 24;16(1):2855. doi: 10.1038/s41467-025-58083-z.
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Total syntheses of cyclohelminthol I-IV reveal a new cysteine-selective covalent reactive group.
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Click Chemistry Methodology: The Novel Paintbrush of Drug Design.
ACS Chem Biol. 2025 Jan 17;20(1):19-32. doi: 10.1021/acschembio.4c00608. Epub 2024 Dec 27.
6
SOF mediated click chemistry enables modular disulfide formation in diverse reaction media.
Nat Commun. 2024 Sep 27;15(1):8325. doi: 10.1038/s41467-024-52606-w.
7
Arginine Accelerates Sulfur Fluoride Exchange and Phosphorus Fluoride Exchange Reactions between Proteins.
Angew Chem Int Ed Engl. 2024 Nov 18;63(47):e202412843. doi: 10.1002/anie.202412843. Epub 2024 Oct 15.
8
Genetically Enabling Phosphorus Fluoride Exchange Click Chemistry in Proteins.
Chem. 2024 Jun 13;10(6):1868-1884. doi: 10.1016/j.chempr.2024.02.010. Epub 2024 Mar 5.
9
The Certainty of a Few Good Reactions.
Chem. 2023 Aug 10;9(8):2063-2077. doi: 10.1016/j.chempr.2023.03.017. Epub 2023 Apr 19.
10
Sulfur fluoride exchange.
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本文引用的文献

1
Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins.
J Am Chem Soc. 2019 May 15;141(19):7698-7703. doi: 10.1021/jacs.9b02611. Epub 2019 May 3.
2
Protein-Catalyzed Capture Agents.
Chem Rev. 2019 Sep 11;119(17):9950-9970. doi: 10.1021/acs.chemrev.8b00660. Epub 2019 Mar 6.
3
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.
Angew Chem Int Ed Engl. 2019 Mar 26;58(14):4552-4556. doi: 10.1002/anie.201813761. Epub 2019 Feb 27.
4
Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.
Mol Syst Des Eng. 2018 Aug 1;3(4):599-603. doi: 10.1039/C8ME00011E. Epub 2018 Jun 7.
5
Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry.
Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11162-11167. doi: 10.1073/pnas.1813574115. Epub 2018 Oct 15.
6
Autocatalytic Synthesis of Bifluoride Ionic Liquids by SuFEx Click Chemistry.
Angew Chem Int Ed Engl. 2018 Dec 3;57(49):16005-16009. doi: 10.1002/anie.201808304. Epub 2018 Sep 3.
7
Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.
Chemistry. 2018 Jul 20;24(41):10550-10556. doi: 10.1002/chem.201802356. Epub 2018 Jun 27.
8
Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction.
Chemistry. 2018 Aug 1;24(43):10948-10952. doi: 10.1002/chem.201802380. Epub 2018 Jul 18.
9
1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry.
Chem Commun (Camb). 2018 Jun 8;54(47):6020-6023. doi: 10.1039/c8cc03400a.

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