Homer Joshua A, Xu Long, Kayambu Namitharan, Zheng Qinheng, Choi Eun Joung, Kim Byeong Moon, Sharpless K Barry, Zuilhof Han, Dong Jiajia, Moses John E
Cancer Center, Cold Spring Harbor Laboratory, 1 Bungtown Road, NY 11724, USA.
Institute of Translational Medicine, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Nat Rev Methods Primers. 2023;3. Epub 2023 Aug 3.
Sulfur Fluoride Exchange (SuFEx) is a click reaction par excellence that has revolutionized multiple research fields. In this Primer, we delve into the essential elements of SuFEx operation, catalysis, and SuFExable connective hubs. We also explore the cutting-edge applications of SuFEx in drug development, polymer science, and biochemistry. Additionally, we examine the potential limitations and promising prospects for this versatile click reaction.
硫氟交换反应(SuFEx)是一种卓越的点击反应,它彻底改变了多个研究领域。在本入门介绍中,我们深入探讨了SuFEx操作、催化以及可进行SuFEx反应的连接枢纽的基本要素。我们还探索了SuFEx在药物开发、聚合物科学和生物化学方面的前沿应用。此外,我们研究了这种多功能点击反应的潜在局限性和广阔前景。