Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
Biosci Rep. 2019 Sep 20;39(9). doi: 10.1042/BSR20190691. Print 2019 Sep 30.
To evaluate the diagnostic value of Epstein-Barr virus (EBV) DNA in nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence.
Articles related to the diagnosis of recurrent or metastatic NPC by the detection of EBV DNA in plasma or serum were retrieved from different databases. Sensitivity, specificity, summary receiver operating characteristic (SROC) curves, and likelihood ratios were pooled to assess the diagnostic value of individual diagnostic tests.
This meta-analysis pooled 25 eligible studies including 2496 patients with NPC. The sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood ratio (-LR) of EBV DNA in the diagnosis of NPC were 0.858 (95% confidence interval (CI): 0.801-0.901), 0.890 (95% CI: 0.866-0.909), 7.782 (95% CI: 6.423-9.429) and 0.159 (95% CI: 0.112-0.226), respectively. The diagnostic odds ratio (DOR) was 48.865 (95% CI: 31.903-74.845). The SROC for EBV DNA detection was 0.93 (95% CI: 0.90-0.95).
The detection of EBV DNA for the diagnosis of recurrent or metastatic NPC has good sensitivity and specificity and might be helpful in monitoring recurrent or metastatic NPC.
评估 Epstein-Barr 病毒 (EBV) DNA 在局部区域或远处复发的鼻咽癌 (NPC) 患者中的诊断价值。
从不同的数据库中检索到与通过检测血浆或血清中的 EBV DNA 诊断复发性或转移性 NPC 相关的文章。汇总敏感性、特异性、综合受试者工作特征 (SROC) 曲线和似然比，以评估各个诊断测试的诊断价值。
这项荟萃分析汇总了 25 项符合条件的研究，共纳入 2496 名 NPC 患者。EBV DNA 对 NPC 的诊断灵敏度、特异度、阳性似然比 (+LR) 和阴性似然比 (-LR) 分别为 0.858（95%置信区间 (CI)：0.801-0.901）、0.890（95% CI：0.866-0.909）、7.782（95% CI：6.423-9.429）和 0.159（95% CI：0.112-0.226）。诊断比值比 (DOR) 为 48.865（95% CI：31.903-74.845）。EBV DNA 检测的 SROC 为 0.93（95% CI：0.90-0.95）。
检测 EBV DNA 对复发性或转移性 NPC 的诊断具有良好的灵敏度和特异性，可能有助于监测复发性或转移性 NPC。
