Suryani Luvita, Lee Hazel P Y, Teo Wei Keat, Chin Zhi Kang, Loh Kwok Seng, Tay Joshua K
Department of Otolaryngology-Head & Neck Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Department of Otolaryngology-Head & Neck Surgery, National University Hospital, Singapore 119228, Singapore.
Cancers (Basel). 2024 Feb 24;16(5):918. doi: 10.3390/cancers16050918.
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) driven malignancy arising from the nasopharyngeal epithelium. Current treatment strategies depend on the clinical stage of the disease, including the extent of the primary tumour, the extent of nodal disease, and the presence of distant metastasis. With the close association of EBV infection with NPC development, EBV biomarkers have shown promise in predicting treatment outcomes. Among the omic technologies, RNA and miRNA signatures have been widely studied, showing promising results in the research setting to predict treatment response. The transformation of radiology images into measurable features has facilitated the use of radiomics to generate predictive models for better prognostication and treatment selection. Nonetheless, much of this work remains in the research realm, and challenges remain in clinical implementation.
鼻咽癌（NPC）是一种由爱泼斯坦-巴尔病毒（EBV）驱动的、起源于鼻咽上皮的恶性肿瘤。当前的治疗策略取决于疾病的临床分期，包括原发肿瘤的范围、淋巴结疾病的范围以及远处转移的存在情况。由于EBV感染与NPC发生密切相关，EBV生物标志物在预测治疗结果方面已显示出前景。在组学技术中，RNA和miRNA特征已得到广泛研究，在研究环境中预测治疗反应方面显示出有前景的结果。将放射学图像转化为可测量特征促进了放射组学的应用，以生成预测模型用于更好的预后评估和治疗选择。尽管如此，这项工作大多仍处于研究领域，临床实施中仍存在挑战。
