Khalili Marian, Daniels Lynsey, Lin Abraham, Krebs Fred C, Snook Adam E, Bekeschus Sander, Bowne Wilbur B, Miller Vandana
Division of Surgery Oncology, Department of Surgery, Drexel University College of Medicine, Philadelphia, PA.
Plasma, Laser Ablation, and Surface Modeling (PLASMANT) Group, Department of Chemistry, University of Antwerp.
J Phys D Appl Phys. 2019 Oct 22;52(42). doi: 10.1088/1361-6463/ab31c1. Epub 2019 Aug 6.
Recent advances in biomedical research in cancer immunotherapy have identified the use of an oxidative stress-based approach to treat cancers, which works by inducing immunogenic cell death (ICD) in cancer cells. Since the anti-cancer effects of non-thermal plasma (NTP) are largely attributed to the reactive oxygen and nitrogen species that are delivered to and generated inside the target cancer cells, it is reasonable to postulate that NTP would be an effective modality for ICD induction. NTP treatment of tumors has been shown to destroy cancer cells rapidly and, under specific treatment regimens, this leads to systemic tumor-specific immunity. The translational benefit of NTP for treatment of cancer relies on its ability to enhance the interactions between NTP-exposed tumor cells and local immune cells which initiates subsequent protective immune responses. This review discusses results from recent investigations of NTP application to induce immunogenic cell death in cancer cells. With further optimization of clinical devices and treatment protocols, NTP can become an essential part of the therapeutic armament against cancer.
癌症免疫疗法的生物医学研究最近取得的进展确定了使用基于氧化应激的方法来治疗癌症，该方法通过诱导癌细胞发生免疫原性细胞死亡（ICD）起作用。由于非热等离子体（NTP）的抗癌作用很大程度上归因于传递到靶癌细胞内部并在其中产生的活性氧和氮物种，因此可以合理推测NTP将是诱导ICD的有效方式。已证明NTP治疗肿瘤可迅速破坏癌细胞，并且在特定治疗方案下，这会导致全身性肿瘤特异性免疫。NTP治疗癌症的转化益处依赖于其增强暴露于NTP的肿瘤细胞与局部免疫细胞之间相互作用的能力，从而引发后续的保护性免疫反应。本综述讨论了最近关于NTP应用以诱导癌细胞发生免疫原性细胞死亡的研究结果。随着临床设备和治疗方案的进一步优化，NTP可以成为抗癌治疗武器库的重要组成部分。
