Bharat Ashwini, Mehta Anita, Tiwari Harish Chandra, Sharma Bhupendra, Singh Abhishek, Singh Vijay
Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
Department of Pediatrics, BRD Medical College, Gorakhpur, Uttar Pradesh, India.
Indian J Crit Care Med. 2019 Aug;23(8):352-355. doi: 10.5005/jp-journals-10071-23217.
Acute kidney injury (AKI) became an important cause of mortality and morbidity in critically ill children, despite advancement in its management. In developing countries etiology of AKI are different from that of developed countries.
This observational study was carried out in pediatric intensive care unit (PICU) in 2 months to18 years of critically ill children. Kidney injury was defined and categorized by the pRIFLE criteria.
Out of 361children, 86 children (23.8%) developed AKI at some point during admission, 275 children (age and sex matched) who did not develop kidney injury during hospitalization served as non-AKI children. Maximum cases of AKI were seen in 1-5 years of age. Maximum children of AKI were of viral encephalitis (n = 43, 50.0%) followed by scrub typhus (n = 14, 16.3%). Risk factors for the development of AKI were shock, PRISM score and longer hospital stay. In our study the mortality in AKI children (n = 30, 34.8%) was significantly higher ( = 0.005) as compared to non-AKI children (n = 56, 20.3%)). Duration on mechanical ventilation, PICU stay and hospital stay were also significantly ( = 0.001) higher in AKI children.
AKI is common in critically ill children and associated with high mortality and morbidity.
Bharat A, Mehta A, Tiwari HC, Sharma B, Singh A, Singh V. Spectrum and Immediate Outcome of Acute Kidney Injury in a Pediatric Intensive Care Unit: A Snapshot Study from Indian Subcontinent. Indian J Crit Care Med 2019;23(8):352-355.
尽管急性肾损伤（AKI）的治疗取得了进展，但它仍是危重症儿童死亡和发病的重要原因。在发展中国家，AKI的病因与发达国家不同。
本观察性研究在儿科重症监护病房（PICU）对2个月至18岁的危重症儿童进行。根据pRIFLE标准对肾损伤进行定义和分类。
在361名儿童中，86名儿童（23.8%）在入院期间的某个时间点发生了AKI，275名在住院期间未发生肾损伤的儿童（年龄和性别匹配）作为非AKI儿童。AKI的最大病例数出现在1至5岁年龄段。AKI患儿中病毒脑炎最多（n = 43，50.0%），其次是恙虫病（n = 14，16.3%）。AKI发生的危险因素包括休克、PRISM评分和住院时间延长。在我们的研究中，AKI患儿的死亡率（n = 30，34.8%）显著高于非AKI患儿（n = 56，20.3%）（P = 0.005）。AKI患儿的机械通气时间、PICU住院时间和总住院时间也显著更长（P = 0.001）。
AKI在危重症儿童中很常见，且与高死亡率和高发病率相关。
Bharat A, Mehta A, Tiwari HC, Sharma B, Singh A, Singh V. 儿科重症监护病房急性肾损伤的谱及近期结局：来自印度次大陆的一项简要研究。《印度危重症医学杂志》2019；23(8):352 - 355。
