Wuhan Center for Disease Control and Prevention, Wuhan 430015, China.
School of Health Sciences, Wuhan University, Wuhan 430071, China.
Oxid Med Cell Longev. 2019 Aug 14;2019:9273056. doi: 10.1155/2019/9273056. eCollection 2019.
BACKGROUND/AIMS: Nucleotide diversity may affect the immune regulation of tuberculosis (TB) patients, leading to the individual susceptibility to TB. In recent years, there are a lot of researches on the association of host genetic factors and TB susceptibility which has attracted increasing attention, and the in-depth study of its mechanism is gradually clear.
We made a minireview on the association of many candidate genes with TB based on recent research studies systematically, such as the human leukocyte antigen (HLA) gene, the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor (P2X7) gene. The discovery of these candidate genes could reveal the pathogenesis of TB comprehensively and is crucial to provide scientific evidence for formulating the related measures of prevention and cure.
The host genes play important roles in the development of TB, and the host genes may become new targets for the prevention and treatment of TB. Effective regulation of host genes may help prevent or even treat TB.
This minireview focuses on the association of host genes with the development of TB, which may supply some clues for future therapies and novel drug targets for TB.
背景/目的：核苷酸多样性可能影响结核病（TB）患者的免疫调节，导致个体易患 TB。近年来，宿主遗传因素与 TB 易感性的相关性研究较多，引起了越来越多的关注，其机制的深入研究也逐渐清晰。
我们系统地综述了许多候选基因与 TB 的相关性，如人类白细胞抗原（HLA）基因、溶质载体家族 11 成员 1（SLC11A1）基因系统、维生素 D 受体（VDR）基因、甘露聚糖结合凝集素（MBL）基因、一氧化氮合酶 2A（NOS2A）基因、斑点 110（SP110）基因和嘌呤能受体 2X7（P2X7）基因。这些候选基因的发现可以全面揭示 TB 的发病机制，为制定相关防治措施提供科学依据至关重要。
宿主基因在 TB 的发生发展中起重要作用，宿主基因可能成为 TB 防治的新靶点。宿主基因的有效调控可能有助于预防甚至治疗 TB。
本综述重点介绍了宿主基因与 TB 发病机制的相关性，为 TB 的未来治疗提供了一些线索，并为新型药物靶点提供了一些线索。
