Pemathilaka Rajeendra L, Reynolds David E, Hashemi Nicole N
Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA.
Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
Interface Focus. 2019 Oct 6;9(5):20190031. doi: 10.1098/rsfs.2019.0031. Epub 2019 Aug 16.
In the past few decades, the placenta became a very controversial topic that has had many researchers and pharmacists discussing the significance of the effects of pharmaceutical drug intake and how it is a possible leading cause towards birth defects. The creation of an microengineered model of the placenta can be used to replicate the interactions between the mother and fetus, specifically pharmaceutical drug intake reactions. As the field of nanotechnology significantly continues growing, nanotechnology will become more apparent in the study of medicine and other scientific disciplines, specifically microengineering applications. This review is based on past and current research that compares the feasibility and testing of the placenta-on-a-chip microengineered model to the previous and underdeveloped and approaches. The testing of the practicality and effectiveness of the , and models requires the experimentation of prominent pharmaceutical drugs that most mothers consume during pregnancy. In this case, these drugs need to be studied and tested more often. However, there are challenges associated with the , and processes when developing a practical placental model, which are discussed in further detail.
在过去几十年里，胎盘成为了一个极具争议的话题，许多研究人员和药剂师都在讨论药物摄入的影响及其重要性，以及它如何可能是导致出生缺陷的主要原因。胎盘微工程模型的创建可用于复制母亲与胎儿之间的相互作用，特别是药物摄入反应。随着纳米技术领域的持续显著发展，纳米技术在医学和其他科学学科的研究中将变得更加明显，特别是在微工程应用方面。这篇综述基于过去和当前的研究，将芯片上胎盘微工程模型的可行性和测试与之前欠发达的方法进行了比较。对[具体模型名称]模型的实用性和有效性进行测试，需要对大多数母亲在怀孕期间服用的知名药物进行实验。在这种情况下，这些药物需要更频繁地进行研究和测试。然而，在开发实用的胎盘模型时，[具体模型名称]的过程存在一些挑战，将在下文进一步详细讨论。
