Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E Young Dr. E, Los Angeles, CA, 90095-1600, USA.
Department of Bioengineering, University of California, Los Angeles, 5121 Engineering 5, Los Angeles, CA, 90095-1600, USA.
Macromol Biosci. 2020 Jan;20(1):e1900243. doi: 10.1002/mabi.201900243. Epub 2019 Sep 4.
The preparation of new diblock copolypeptide hydrogels derived from homologs of l-methionine, that is, l-homomethionine and l-6-(methylthio)-l-norleucine is described. Compared to l-methionine residues, use of l-methionine homologs allow improved copolymerization with l-leucine residues to give well-defined block copolypeptides. These copolypeptides are subsequently modified using robust thioether alkylation reactions employing a variety of functional epoxides, which yield samples capable of forming transparent, self-healing hydrogels in water. The facile variation of different functional epoxides for postpolymerization modification is found to allow predictable functionalization and tuning of hydrogel properties by the modification of simple precursors.
描述了由 l-同型蛋氨酸（即 l-高蛋氨酸）和 l-6-（甲硫基）-l-正亮氨酸的类似物衍生的新型两亲嵌段共多肽水凝胶的制备。与 l-蛋氨酸残基相比，使用 l-蛋氨酸类似物可改善与 l-亮氨酸残基的共聚反应，从而得到具有明确结构的嵌段共多肽。然后使用各种功能环氧化物通过坚固的硫醚烷基化反应对这些共多肽进行修饰，生成能够在水中形成透明自修复水凝胶的样品。发现通过聚合后修饰的不同功能环氧化物的简便变化可通过修饰简单的前体来实现对水凝胶性质的可预测的官能化和调谐。
