Department of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.
J Am Chem Soc. 2017 Oct 25;139(42):15114-15121. doi: 10.1021/jacs.7b08190. Epub 2017 Oct 12.
Synthetic diblock copolypeptides were designed to incorporate oppositely charged ionic segments that form β-sheet-structured hydrogel assemblies via polyion complexation when mixed in aqueous media. The observed chain conformation directed assembly was found to be required for efficient hydrogel formation and provided distinct and useful properties to these hydrogels, including self-healing after deformation, microporous architecture, and stability against dilution in aqueous media. While many promising self-assembled materials have been prepared using disordered or liquid coacervate polyion complex (PIC) assemblies, the use of ordered chain conformations in PIC assemblies to direct formation of new supramolecular morphologies is unprecedented. The promising attributes and unique features of the β-sheet-structured PIC hydrogels described here highlight the potential of harnessing conformational order derived from PIC assembly to create new supramolecular materials.
合成二嵌段共聚多肽被设计为包含带相反电荷的离子段，当在水介质中混合时，通过聚离子复合形成β-折叠结构的水凝胶组装体。观察到的链构象指导组装对于有效形成水凝胶是必需的，并为这些水凝胶提供了独特且有用的性质，包括变形后的自修复、微孔结构以及在水介质中稀释的稳定性。虽然已经使用无序或液体凝聚聚离子复合物 (PIC) 组装体制备了许多有前途的自组装材料，但在 PIC 组装体中使用有序链构象来指导新超分子形态的形成是前所未有的。这里描述的β-折叠结构 PIC 水凝胶的有前途的属性和独特的特征突出了利用源自 PIC 组装的构象有序性来创建新的超分子材料的潜力。
