Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makka, Saudi Arabia.
Crit Rev Anal Chem. 2020;50(6):485-500. doi: 10.1080/10408347.2019.1657793. Epub 2019 Sep 5.
The evolution in foodstuff-monitoring processes has increased the number of studies on biogenic amines (BAs), in recent years. This trend with future perspective needs to be assembled to address the associated health risks. Thus, this study aims to cover three main aspects of BAs: (i) occurrence, physiology, and toxicological effects, most probable formation mechanisms and factors controlling their growth; (ii) recent advances, strategies for determination, preconcentration steps, model technique, and nature of the matrix; and (iii) milestone, limitations with existing methodologies, future trends, and detailed expected developments for clinical use and on-site ultra-trace determination. The core of the ongoing review will discuss recent trends in pre-concentration toward miniaturization, automation, and possible coupling with electrochemical techniques, surface-enhanced Raman scattering, spectrofluorimetry, and lateral flow protocols to be exploited for the development of rapid, facile, and sensitive determination strategies for BAs.
近年来，食品监测过程的发展使得越来越多的研究关注生物胺（BAs）。这种具有未来前景的趋势需要加以整合，以应对相关的健康风险。因此，本研究旨在涵盖 BAs 的三个主要方面：（i）生物胺的存在、生理学和毒理学效应、最可能的形成机制以及控制其生长的因素；（ii）生物胺的最新进展、测定策略、预浓缩步骤、模型技术和基质的性质；以及（iii）生物胺的里程碑、现有方法的局限性、未来趋势以及临床应用和现场痕量测定的详细预期发展。正在进行的综述的核心将讨论朝着小型化、自动化以及与电化学技术、表面增强拉曼散射、荧光光谱法和横向流动方案可能的偶联的预浓缩的最新趋势，这些技术将被用于开发快速、简便和灵敏的 BAs 测定策略。
