Ley R
State University of New York, Albany 12222.
J Behav Ther Exp Psychiatry. 1988 Sep;19(3):181-92. doi: 10.1016/0005-7916(88)90039-0.
Panic attacks during sleep are analysed in terms of a hyperventilation theory of panic disorder. The theory assumes that panic attacks during sleep are a manifestation of severe chronic hyperventilation, a dysfunctional state in which renal compensation has led to a relatively steady state of diminished bicarbonate. Reductions in respiration during deep non-REM sleep lead to respiratory acidosis which triggers hyperventilatory hypocapnea and subsequent panic. A probability model designed to predict when during sleep panic attacks are likely to occur is supported by relevant data from studies of sleep and panic attacks. Implications for treatment are discussed.
根据惊恐障碍的换气过度理论对睡眠期间的惊恐发作进行了分析。该理论认为，睡眠期间的惊恐发作是严重慢性换气过度的一种表现，这是一种功能失调状态，其中肾脏代偿导致了碳酸氢盐减少的相对稳定状态。深度非快速眼动睡眠期间呼吸的减少会导致呼吸性酸中毒，从而引发换气过度性低碳酸血症及随后的惊恐发作。一个旨在预测睡眠期间何时可能发生惊恐发作的概率模型得到了睡眠与惊恐发作研究的相关数据支持。文中还讨论了对治疗的启示。
