Craske M G, Barlow D H
Center for Stress and Anxiety Disorders, University at Albany, State University of New York.
J Abnorm Psychol. 1990 Aug;99(3):302-7. doi: 10.1037//0021-843x.99.3.302.
To examine the role of ventilatory response in nocturnal panic, subjects experiencing nocturnal panic were compared with those who experienced daytime panic attacks only. In particular, measures of chronic hyperventilation (baseline pCO2) and CO2 hypersensitivity (response to ventilatory challenges) were assessed. Subjective and psychophysiological measures were obtained during baseline, forced hyperventilation, and carbon dioxide inhalation phases of a standardized laboratory-based assessment. The groups did not differ with respect to subjective or physiological measures or to the frequency with which panic occurred during the assessment. The results do not lend support to models that emphasize central CO2 hypersensitivity and chronic hyperventilation as primary mechanisms underlying nocturnal panic.
为了研究通气反应在夜间惊恐发作中的作用，将经历夜间惊恐发作的受试者与仅经历白天惊恐发作的受试者进行了比较。具体而言，评估了慢性过度通气（基线二氧化碳分压）和二氧化碳高敏反应（对通气挑战的反应）的指标。在基于标准化实验室评估的基线、强迫性过度通气和二氧化碳吸入阶段，获取了主观和心理生理指标。两组在主观或生理指标方面，以及在评估期间惊恐发作的频率方面均无差异。这些结果不支持将中枢性二氧化碳高敏反应和慢性过度通气强调为夜间惊恐发作潜在主要机制的模型。
