对烯丙基-醌甲川化合物（VQMs）的对映选择性有机催化活化。
Enantioselective organocatalytic activation of vinylidene-quinone methides (VQMs).
机构信息
Aix Marseille Université, CNRS, Centrale Marseille, iSm2, Marseille, France.
出版信息
Chem Commun (Camb). 2019 Sep 17;55(75):11168-11170. doi: 10.1039/c9cc05097c.
PMID:31486436
Abstract
Vinylidene-quinone methides (VQMs) are highly electrophilic chiral reagents that can be generated in situ from 2-(phenylethynyl)phenols. They were characterized for the first time in 2012 but their enantioselective organocatalytic activation was addressed only very recently. Their specific reactivity has revealed innovative strategies notably for the control of axial chirality.
摘要
亚乙烯基醌甲川类化合物（VQMs）是一种高亲电性的手性试剂，可由 2-（苯乙炔基）苯酚原位生成。它们于 2012 年首次被描述，但它们的对映选择性的有机催化活化最近才被涉及。它们的特殊反应性揭示了创新的策略，特别是用于控制轴向手性。
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