Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", Bari, Italy.
Department of metabolic diseases, clinic genetics and diabetology, "Giovanni XXIII" Children's Hospital, Bari, Italy.
Endocr Metab Immune Disord Drug Targets. 2020;20(3):351-355. doi: 10.2174/1871530319666190905161347.
Immune thrombocytopenia (ITP) is an acquired immune mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients can develop autoantibodies such as anti-thyroglobulin (TG) and anti-thyroperoxidase (TPO), even in the absence of clinical signs of autoimmune disease.
The purpose of this article is to provide a review about: 1) the prevalence of positivity of anti-thyroid antibodies (TPO and TG) in pediatric patients with chronic ITP; 2) the role of autoimmune thyroiditis on the outcome of chronic ITP.
The authors individually completed a review of the literature for this article. Retrospective and prospective clinical studies with pediatric cohorts were considered.
From the analysis of data, we found 4 papers which included studies only on pediatric population, and which corresponded to selected criteria. Pediatric ITP patients have been shown to have a statistically significant prevalence of anti-thyroid antibodies over healthy controls (11.6-36% versus 1.2-1.3%). No correlation has been found between the platelet count and the prevalence of positive anti-thyroid antibodies at any time of the follow up.
The results of our bibliographic research demonstrated that: a) pediatric patients with chronic ITP tend to have a statistically significant prevalence of anti-thyroid antibodies positivity respect to general pediatric population; b) there are no clear data about the role of autoimmune thyroiditis as prognostic factor for chronic course of ITP in pediatric age.
免疫性血小板减少症（ITP）是一种由自身免疫介导的获得性疾病，其特征为孤立性血小板减少。儿科 ITP 患者可产生自身抗体，如抗甲状腺球蛋白（TG）和抗甲状腺过氧化物酶（TPO）抗体，即使在无自身免疫性疾病临床征象的情况下也是如此。
本文旨在综述：1）慢性 ITP 儿科患者抗甲状腺抗体（TPO 和 TG）阳性率；2）自身免疫性甲状腺炎对慢性 ITP 结局的影响。
作者对本文进行了文献复习。纳入了针对儿科人群的回顾性和前瞻性临床研究。
数据分析发现，符合入选标准的研究共 4 篇，均为儿科人群的研究。与健康对照组相比，儿科 ITP 患者的抗甲状腺抗体阳性率具有统计学意义（11.6-36%对 1.2-1.3%）。在随访的任何时间，血小板计数与抗甲状腺抗体阳性率之间均无相关性。
文献研究结果表明：a）慢性 ITP 儿科患者的抗甲状腺抗体阳性率显著高于普通儿科人群；b）自身免疫性甲状腺炎是否为 ITP 慢性病程的预后因素尚不清楚。
