Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Neuroscience Program, Vanderbilt University, Nashville, TN, USA.
Adv Exp Med Biol. 2019;1169:1-30. doi: 10.1007/978-3-030-24108-7_1.
In this chapter, heterogeneity is explored in the context of the ventricular-subventricular zone, the largest stem cell niche in the mammalian brain. This niche generates up to 10,000 new neurons daily in adult mice and extends over a large spatial area with dorso-ventral and medio-lateral subdivisions. The stem cells of the ventricular-subventricular zone can be subdivided by their anatomical position and transcriptional profile, and the stem cell lineage can also be further subdivided into stages of pre- and post-natal quiescence and activation. Beyond the stem cells proper, additional differences exist in their interactions with other cellular constituents of the niche, including neurons, vasculature, and cerebrospinal fluid. These variations in stem cell potential and local interactions are discussed, as well as unanswered questions within this system.
在这一章中，我们将探讨室下区（哺乳动物大脑中最大的干细胞龛）中的异质性。该龛在成年小鼠中每天可产生多达 10000 个新神经元，并在背腹和内外侧区域延伸较大的空间。室下区的干细胞可以根据其解剖位置和转录谱进行细分，干细胞谱系也可以进一步细分为产前和产后静止和激活阶段。除了真正的干细胞之外，它们与龛内其他细胞成分（包括神经元、血管和脑脊液）的相互作用也存在差异。我们将讨论这些干细胞潜能和局部相互作用的差异，以及该系统中未解决的问题。
