Department of Molecular, Cellular and Development Neurobiology, Instituto Cajal-CSIC, 28002 Madrid, Spain.
Genes (Basel). 2020 Mar 13;11(3):305. doi: 10.3390/genes11030305.
The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their molecular profiles remain unknown. Using modified StarTrack genetic tracing strategies, specific SVZ progenitor cells were targeted in E12 mice embryos, and the cell fate of these neural progenitors was determined in the adult olfactory bulb. This study defined the distribution and the phenotypic diversity of olfactory bulb interneurons from specific SVZ-progenitor cells, focusing on their spatial pallial origin, heterogeneity, and genetic profile.
嗅球的表型变异较大，可能与前体细胞的异质性有关。因此，特别关注源自侧脑室下区（SVZ）前体细胞的后代，因为这些前体细胞有许多方面，其分子特征尚不清楚。使用改良的 StarTrack 遗传追踪策略，在 E12 胚胎小鼠中靶向特定的 SVZ 前体细胞，并在成年嗅球中确定这些神经前体细胞的命运。本研究定义了特定 SVZ 前体细胞来源的嗅球中间神经元的分布和表型多样性，重点关注它们的空间皮质起源、异质性和遗传特征。
