山茱萸果实中的两个新裂环环烯醚萜葡萄糖苷：cornusglucosides A 和 B。

Cornusglucosides A and B, Two New Iridoid Glucosides from the Fruit of Cornus officinalis.

机构信息

Department of Pharmacy & Department of TCM Rheumatism & Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, P. R. China.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China.

出版信息

Chem Biodivers. 2019 Nov;16(11):e1900421. doi: 10.1002/cbdv.201900421. Epub 2019 Sep 30.

DOI:10.1002/cbdv.201900421

Abstract

Phytochemical study on the fruit of Cornus officinalis Sieb. et Zucc. yielded two new iridoid glucosides, named cornusglucoside A (1) and cornusglucoside B (2). The structures of 1 and 2 were elucidated via comprehensive NMR and HR-ESI-MS data analysis. Additionally, their inhibitory effects on IL-6-induced STAT3 activation were assessed.

摘要

山茱萸果实的化学成分研究得到了两个新的裂环环烯醚萜糖苷，分别命名为山茱萸苷 A（1）和山茱萸苷 B（2）。通过全面的 NMR 和 HR-ESI-MS 数据分析阐明了它们的结构。此外，还评估了它们对 IL-6 诱导的 STAT3 激活的抑制作用。

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