School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China.
Molecules. 2022 Jul 24;27(15):4732. doi: 10.3390/molecules27154732.
Four previously undescribed iridoid glycosides neocornuside A-D (), along with six known ones (), were isolated from fruit. Their structures were elucidated by extensive spectroscopic (NMR, UV, IR, and MS) analysis and comparison with data reported in the literature. All isolates were assessed for their antidiabetic activity on the relative glucose consumption in insulin-induced insulin-resistant HepG2 cells. The results showed that compounds , , and exhibited significant antidiabetic activities with EC values of 0.582, 1.275, and 0.742 μM, respectively. Moreover, compounds , , and could improve the ability of 2-NBDG uptake of insulin-induced HepG2 cells.
从 果实中分离得到了 4 个以前未描述的裂环环烯醚萜糖苷 neo 玉米素 A-D ()，以及 6 个已知的糖苷 ()。通过广泛的光谱 (NMR、UV、IR 和 MS) 分析和与文献报道的数据进行比较，阐明了它们的结构。所有分离物均评估了它们在胰岛素诱导的胰岛素抵抗 HepG2 细胞中相对葡萄糖消耗方面的抗糖尿病活性。结果表明，化合物 、 、 和 表现出显著的抗糖尿病活性，EC 值分别为 0.582、1.275 和 0.742 μM。此外，化合物 、 、 和 可以提高胰岛素诱导的 HepG2 细胞摄取 2-NBDG 的能力。
