Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada; email:
Annu Rev Genet. 2019 Dec 3;53:373-392. doi: 10.1146/annurev-genet-112618-043536. Epub 2019 Sep 5.
The () gene is a well-established example of a gene with major effects on behavior and natural variation. This gene is best known for underlying the behavioral strategies of rover and sitter foraging larvae, having been mapped and named for this phenotype. Nevertheless, in the last three decades an extensive array of studies describing 's role as a modifier of behavior in a wide range of phenotypes, in both and other organisms, has emerged. Furthermore, recent work reveals new insights into the genetic and molecular underpinnings of how affects these phenotypes. In this article, we discuss the history of the gene and its role in natural variation in behavior, plasticity, and behavioral pleiotropy, with special attention to recent findings on the molecular structure and transcriptional regulation of this gene.
() 基因是一个行为和自然变异的主要影响因素的基因的典型例子。这个基因最为人所知的是，它是流浪觅食幼虫和定居觅食幼虫这两种行为策略的基础，因此这个基因也因此表型而被定位和命名。然而，在过去的三十年中，大量描述“”作为广泛表型的行为修饰因子的作用的研究已经出现，这些研究不仅在果蝇中，也在其他生物中进行。此外，最近的工作揭示了关于“”如何影响这些表型的遗传和分子基础的新见解。在本文中，我们讨论了基因的历史及其在行为、可塑性和行为多效性的自然变异中的作用，特别关注了关于这个基因的分子结构和转录调控的最新发现。
