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Dexamethasone for the treatment of class I HELLP syndrome: A double-blind, placebo-controlled, multicenter, randomized clinical trial.

作者信息

Fonseca Javier E, Otero Juan C, Messa Clara

机构信息

Universidad del Valle, Department of Gynecology and Obstetrics (MUGER research group) and Hospital Universitario del Valle, Calle 5 # 36-08. Cali, 760042, Colombia.

Universidad Industrial de Santander and Hospital Universitario de Santander, Carrera 33 # 28, 126, Bucaramanga 680001, Colombia.

出版信息

Pregnancy Hypertens. 2019 Jul;17:158-164. doi: 10.1016/j.preghy.2019.06.003. Epub 2019 Jun 17.

DOI:10.1016/j.preghy.2019.06.003
PMID:31487635
Abstract
摘要

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1
Dexamethasone for the treatment of class I HELLP syndrome: A double-blind, placebo-controlled, multicenter, randomized clinical trial.地塞米松治疗I级HELLP综合征:一项双盲、安慰剂对照、多中心、随机临床试验。
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2
Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: a double-blind, placebo-controlled, randomized clinical trial.地塞米松治疗不能改善伴有HELLP综合征的女性的预后:一项双盲、安慰剂对照、随机临床试验。
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COHELLP: collaborative randomized controlled trial on corticosteroids in HELLP syndrome.COHELLP:HELLP 综合征皮质类固醇治疗的协作随机对照试验。
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Addition of platelet transfusions to corticosteroids does not increase the recovery of severe HELLP syndrome.在皮质类固醇基础上加用血小板输注并不能增加重度HELLP综合征的恢复。
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Dexamethasone to improve maternal outcome in women with hemolysis, elevated liver enzymes, and low platelets syndrome.地塞米松改善溶血、肝酶升高和血小板减少综合征女性的孕产妇结局。
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A randomised placebo-controlled trial of prolonged prednisolone administration to patients with HELLP syndrome remote from term.一项针对孕周尚早的HELLP综合征患者延长泼尼松龙给药时间的随机安慰剂对照试验。
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A prospective, randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome.一项比较地塞米松和倍他米松治疗产前HELLP(溶血、肝酶升高和血小板计数降低)综合征疗效的前瞻性随机试验。
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[Maternal benefit of postpartum corticosteroid therapy in patients with HELLP (hemolysis elevated liver enzymes low platelets count) syndrome].[产后皮质类固醇治疗对 HELLP(溶血、肝酶升高、血小板计数降低)综合征患者的母体益处]
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引用本文的文献

1
Corticosteroids for improving patient-relevant outcomes in HELLP syndrome: a systematic review and meta-analysis.皮质类固醇治疗 HELLP 综合征改善患者相关结局的疗效:系统评价和荟萃分析。
BMC Pregnancy Childbirth. 2024 Jul 18;24(1):487. doi: 10.1186/s12884-024-06665-y.
2
HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report.采用密西西比方案治疗的孕20周HELLP综合征:一例报告
Kobe J Med Sci. 2024 Apr 1;70(1):E22-E25. doi: 10.24546/0100488386.
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State of the Art in Hepatic Dysfunction in Pregnancy.
妊娠期肝功能障碍的研究现状
Healthcare (Basel). 2021 Oct 31;9(11):1481. doi: 10.3390/healthcare9111481.