Schulz Gerald B, Grimm Tobias, Buchner Alexander, Kretschmer Alexander, Stief Christian G, Karl Alexander, Jokisch Friedrich
Department of Urology, Ludwig-Maximilians-University, Munich, Germany,
Department of Urology, Ludwig-Maximilians-University, Munich, Germany.
Urol Int. 2019;103(3):350-356. doi: 10.1159/000502657. Epub 2019 Sep 5.
Early rehabilitation (ER) after radical cystectomy (RC) seems to be crucial for quality of life, education and prevention of complications after hospital discharge. We investigated an inpatient ER setting for bladder cancer (BC) patients.
In total, 103 BC patients who underwent ileum neobladder reconstruction were included. The major issues from the patients' point of view, functional outcome parameters and complications during ER were analysed. A Wilcoxon signed rank test was used to compare body mass index (BMI) and diurnal as well as nocturnal use of urinary pads before and after ER.
At the beginning of ER, the median Karnovsky performance scale score was 70% (interquartile range [IQR] 70-90%) and the mean BMI was 25.8 kg/m2 (IQR 21.9-27.9). The 4 most common complaints were urinary incontinence (80.6%), general weakness (73.8%), urinary mucus (49.5%) and mental distress (44.7%). During the programme, 28.2% of patients had a urinary tract infection requiring antibiotics and 15.5% presented a symptomatic acidosis. Median diurnal use of urinary pads significantly decreased during ER (4 vs. 3; p < 0.001). At the end of the ER programme, 76.0, 54.8 and 30.8% of the patients indicated an improvement of their physical capacity, incontinence and psychological distress respectively.
Our study demonstrates the need for postoperative rehabilitation after RC. Further investigations should compare outcome parameters to ambulatory and outpatient ER models.
根治性膀胱切除术后的早期康复对于生活质量、教育以及出院后并发症的预防似乎至关重要。我们研究了针对膀胱癌患者的住院早期康复方案。
总共纳入了103例行回肠新膀胱重建术的膀胱癌患者。分析了从患者角度出发的主要问题、早期康复期间的功能结局参数以及并发症。采用Wilcoxon符号秩检验比较早期康复前后的体重指数(BMI)以及日间和夜间尿垫的使用情况。
在早期康复开始时,卡诺夫斯基功能状态量表评分中位数为70%(四分位间距[IQR]70 - 90%),平均BMI为25.8kg/m²(IQR 21.9 - 27.9)。4个最常见的主诉是尿失禁(80.6%)、全身无力(73.8%)、尿道黏液(49.5%)和精神困扰(44.7%)。在康复计划期间,28.2%的患者发生需要使用抗生素的尿路感染,15.5%出现有症状的酸中毒。早期康复期间日间尿垫使用中位数显著减少(4对3;p < 0.001)。在早期康复计划结束时,分别有76.0%、54.8%和30.8%的患者表示其身体能力、尿失禁和心理困扰有所改善。
我们的研究表明根治性膀胱切除术后需要进行术后康复。进一步的研究应将结局参数与门诊和非住院早期康复模式进行比较。