Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine III, Jena University Hospital, Jena, Germany.
Exp Clin Endocrinol Diabetes. 2021 Aug;129(8):587-592. doi: 10.1055/a-0983-1559. Epub 2019 Sep 5.
The aim of this longitudinal study was to assess outcomes before and one year after participation in a structured inpatient intervention including participation in an education programme for people with type 2 diabetes.
In 2014, 81 individuals, who were admitted to optimise insulin therapy, participated in a structured inpatient intervention and were invited to participate in a follow-up visit after one year.
Seventy participants (46.9% female, age 68.3 y, diabetes duration 17.9 y, HbA1c 9.7%/82.5 mmol/mol) were followed-up after 1.2 y (3 died by non-diabetic causes, 8 declined/were not available). HbA1c decreased by 1.1% (p<0.001) without change of insulin dose (79.7 vs. 79.3 IU, n.s.) or BMI (33.6 vs. 33.8 kg/m, n.s.). 5 people admitted because of severe hypoglycaemia (one person with 5 episodes and 4 with one episode in the year prior to participation) did not experience another event in the evaluation period, nor did anyone in the rest of the cohort (frequency of severe hypoglycaemia 0.12 events/year before and 0.0 after intervention).
In people admitted for optimising insulin therapy or severe hypoglycaemia, metabolic control improved substantially and frequency of severe hypoglycaemia was significantly reduced after participation in a structured inpatient intervention. Reasons could be motivational and better adapted eating habits, tailoring individual therapy solutions and deescalating diabetes therapy in people after severe hypoglycaemia.
本纵向研究旨在评估参与包括 2 型糖尿病患者参与教育计划在内的结构化住院干预前后的结局。
2014 年,81 名因优化胰岛素治疗而住院的患者参与了结构化住院干预,并被邀请在一年后参加随访。
70 名参与者(46.9%为女性,年龄 68.3 岁,糖尿病病程 17.9 年,HbA1c 9.7%/82.5mmol/mol)在 1.2 年后进行了随访(3 人因非糖尿病原因死亡,8 人拒绝/无法参加)。HbA1c 下降 1.1%(p<0.001),而胰岛素剂量(79.7 与 79.3IU,无统计学差异)或 BMI(33.6 与 33.8kg/m,无统计学差异)无变化。5 名因严重低血糖入院的患者(1 人有 5 次,4 人在参与前一年有 1 次)在评估期间未再发生事件,其余患者也未发生事件(严重低血糖发生率为 0.12 次/年,干预前为 0.0 次/年)。
在因优化胰岛素治疗或严重低血糖入院的患者中,代谢控制显著改善,且参与结构化住院干预后严重低血糖的发生频率显著降低。原因可能是干预提高了患者的积极性,改善了饮食习惯,为患者制定了个体化的治疗方案,并在发生严重低血糖后减少了糖尿病治疗的强度。